DNA repair

Study of DNA Repair Synthesis Function in the Elderly

老年期细胞DNA修复功能的研究

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Objective To observe DNA damage induced by advanced glycation end-products ( AGEs) and DNA repair with pyridoxamine ( PM) in mice spleen lymphocytes in vitro.

目的观察吡哆胺（PM）对糖基化终产物（AGEs）诱导的脾淋巴细胞DNA损伤的修复情况。

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The DNA repair function In the peripheral blood lymphocyte of40 ovary cancer patients and100normal people has been determined with classical unscheduled DNA synthesis ( UDS) technic.

对40例卵巢肿瘤患者和100例健康人的外周血淋巴细胞接经典的非顺序性DNA合成法进行DNA修复功能测定。

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Most of the up-regulated genes are related to inflammations and stress responses, but large part of the down-regulated genes play roles in synapse plasticity, vesicular transportation, mitochondria function, protein and DNA repair, and neurohormone secreting.

上调基因多为促炎症、应激反应相关基因；而下调基因则多为突触可塑性、囊泡运输、线粒体功能、蛋白质和DNA修复、神经激素等相关基因。

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Deficiencies in cellular responses to DNA damage can predispose to cancer. Ionizing radiation can cause cluster damage and double-strand breaks ( DSBs) that pose problems for cellular repair processes.

细胞对DNA损伤反应缺陷会诱发肿瘤，电离辐射可引起DNA簇损伤和双链断裂，成为细胞修复过程的问题。

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OBJECTIVE: To investigate RAG gene, DNA repair factors Ku70/ Ku80 and terminal deoxynucleotidyl transferase ( TdT) mRNA expression and T cell receptor ( TCR) gene recombination in human leukemia and lymphoma cell lines.

目的：检测重组激活基因、DNA修复因子Ku70/Ku80和末端脱氧核苷转移酶mRNA表达以及T细胞受体基因重排在人白血病和淋巴瘤细胞株的发生情况。

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The results of the comet assay demonstrated the genotoxicity of metal contaminated soils. And a DNA repair process in earthworm was observed as the exposure time prolonged. And the comet assay is capable of examining the genotoxicity of soils.

彗星试验结果表明重金属污染土壤对蚯蚓产生明显的遗传毒性，并观察到随着暴露时间延长，蚯蚓体内产生DNA修复机制，提示彗星试验是检测土壤基因毒性的有效手段。

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Relationship between polymorphisms of DNA repair genes and glutathione-S-transferase genes and risk of biliary tract cancer

核苷酸切除修复基因和谷胱甘肽-S-转移酶基因多态与胆道癌风险关系的研究

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Replication factor C subunit 2 ( RFC2) was reported to be associated with DNA duplication, DNA repair, and the function of cellular checkpoint.

复制因子C亚单位2（replicationfactorCsubunit2，RFC2）与DNA的复制和修复及细胞周期信号检查点的功能有关。

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Tumor suppressor protein p53 plays a critical role in the maintenance of genomic stability, participating in many cellular processes such as cell cycle checkpoints and DNA repair.

p53蛋白参与了细胞周期检查点和DNA修复等多种生命活动中，在维护基因组完整性中发挥重要的作用。

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Background and Objective: Gastric carcinoma is the most common malignant tumor, whose development maybe associated with the absence of DNA repair function of cells.

背景与目的：胃癌是消化道常见的恶性肿瘤，其发生可能与DNA修复功能缺陷有关。

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Objective: Study the expression of tumor suppressor gene, DNA repair gene and telomerase component in acute leukemia, discuss their effects on the occurrence and development of leukemia and their clinical meanings.

目的：研究抑癌基因、DNA修复基因及端粒酶在白血病细胞中的表达，探讨其对白血病发生、发展的作用和临床意义。

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PFGE analysis of DNA double-strand breaks and DNA repair process in human osteosarcoma cells irra-diated by X-rays

应用脉冲电场凝胶电泳分析X射线诱发人骨肉瘤细胞DNA双链断裂与损伤修复效应

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Conclusion The protective effect of 971 on learning and memory ability of β-AP_ ( 25-35)-treated mouse may be related to the expression changes of genes involved in cell cycle, DNA repair, nerve growth, synaptic plasticity and immune response, etc.

结论酸性寡糖971改善AD模型小鼠学习记忆功能可能与DNA损伤修复、神经生长、突触可塑性、免疫应答等相关基因的表达变化有一定关系。

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Conclusion The curve of DNA repair in vitro of human lymphocytes could be considered in biodosimetry estimation because the process of DNA re-pair in vitro could display the repair level and speed of DNA double-strand break in vivo.

结论人淋巴细胞离体辐照后的修复过程可基本反映体内DNA双链断裂的修复水平与速度，修复曲线可以作为辐射生物剂量估算时的参考。

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Determinants of tumor radiosensitivity are the intrinsic sensitivity of tumor cells, which affected by the cellular DNA double-strand break ( DSB) repair capacity.

肿瘤放射敏感性的决定因素是肿瘤细胞内在敏感性，而影响细胞内在敏感性的最重要因素是细胞DNA双链断裂（DSB）修复能力。

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Scientists know that homologous recombination repair is also required for the repair of DNA cross-links, but the exact details remain to be resolved, Chen said.

科学家知道，DNA交联修复过程中也需要同源生物再结合修复参与，但是精确的细节仍有待研究。

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DNA repair approach has focused on gene targeting or gene replacement whereby the defective gene is removed and a normal gene is inserted at the same position in the chromosome and so it maintains the corrected gene's expression in the natural context.

基因原位修复策略是一种直接的基因疗法，它针对基因缺陷部位进行修复，保持了基因原有的染色质环境，因此是一种理想的靶向性基因治疗方式。

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Apart from DNA repair, non-homologous end joining ( NHEJ) may play a role in V ( D) J recombination, and integration of HIV-1 genome into a host genome, as well as the insertion of pseudogenes and repetitive sequences into the genome of mammalian cells.

非同源末端连接途径除了在DNA双链断裂修复中起重要作用外，在V（D）J重组、HIV-1病毒整合宿主基因，以及假基因和重复序列的插入上也起着重要作用。

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In Escherichia coli, it takes part in conjugational recombination and DNA repair but is not as important as that in archaea.

在大肠杆菌中，RadA蛋白也参与了重组和DNA损伤修复过程，但远没有在古细菌中的功能那么重要。

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The methylation of promoter region CpG islands is one of main ways for inactivating tumor suppressor gene, DNA repair gene and pro-apoptotic gene.

启动子区CpG岛高甲基化（hypermethylation）是抑瘤基因、DNA修复基因、促凋亡基因失活的主要方式之一。

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Purpose: The DNA double-strand breaks ( DSB) and its repair ability of human tumor cell lines after irradiation were detected for studying the correlation to cell radiosensitivity.

目的：检测人类肿瘤细胞系统经X线照射产生的DNA双链断裂（DSB）及其修复过程，初步验证双链断裂及其修复与细胞放射敏感性的关系。

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However, repair of damaged DNA also typically depends on DNA, synthesis.

但是, 损伤DNA的修复主要还是在于DNA合成.

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HIV-1 Tat protein sensitizes cells to ionizing radiation via, at least partially, depressing DNA-PKcs expression and DNA repair.

HIV-1Tat蛋白抑制DNA-PKcs的表达，降低DNA双链断裂的修复，使细胞的电离辐射敏感性增高。

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Which reveals that the Amygdalus communis has the functions of resistance to the mutation and of protecting the chromosomes against harm as well as of promoting the DNA repair.

说明，巴旦杏仁抗突变，保护染色体损伤，有促进DNA修复作用。

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Study of Abnormal NHEJ DNA Repair Function in Myeloid Leukemia

髓系白血病异常NHEJ DNA修复功能的研究

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The DNA repair techniques with Taq DNA polymerase can greatly enhance the success rate of STR genotyping for high degrade samples, which is suitable for the STR genotyping of high degrade samples. 3.

使用taq DNA聚合酶修复技术可以极大地提高高度降解检材STR分型的成功率，适合高度降解检材STR分型的应用。

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Cancer genetics, somatic mutagenesis, DNA repair, genomics and molecular medicine.

肿瘤发生的遗传机制; 体细胞突变的发生机制; DNA修复, 基因组学与分子医学.

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Scientists would alter these cells by inserting genes or activating the cells'DNA-repair mechanisms.

科学家通过注入基因或激活细胞的脱氧糖核酸(DNA)修复机制来造基因.

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Studies on DNA DSB and its rejoining repair in a mutated radiosensitive mouse mammary cancer cell line, sx-9

小鼠乳癌细胞辐射敏感突变株SX-9DNA双链断裂及其重接修复研究

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